Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
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چکیده
منابع مشابه
Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver.
BACKGROUND & AIMS Cholecystokinin (CCK) is a major gastrointestinal peptide hormone that is released postprandially from the small intestine and exerts marked effects on gallbladder and gastrointestinal motility. The smaller isoforms CCK-8 and CCK-4 are rapidly taken up into hepatocytes, metabolized, and excreted into bile. Our aim was to identify and characterize the hepatocellular CCK-8 uptak...
متن کاملInvolvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rat and human
Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China (A.Z., C.W., Q.L., Q.M., J.P., H.S., X.M., X.H., K.L) Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China (C.W., Q.L., Q.M., J.P., H.S., X.M., K.L) Research Institute of Integrated Traditional and Western Medicine of Dalian Medical University, Liaoning,...
متن کاملOrganic anion-transporting polypeptides.
Organic anion-transporting polypeptides or OATPs are central transporters in the disposition of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of endogenous substrates. The critical role of OATPs in drug disposition has spurred research both in academia and in the pharmaceutical industry. Translational aspects with clinical questions are the focus in academia...
متن کاملPolyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.
Hepatic uptake of albumin-bound amphipathic organic cations has been suggested to be mediated by multispecific bile salt and organic anion transport systems. Therefore, we investigated whether the recently cloned rat organic anion transporting polypeptides 1 and 2 as well as the human organic anion transporting polypeptide might be involved in the hepatocellular uptake of bulky type II organic ...
متن کاملInvolvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
The objective of this study was to clarify the mechanism underlying hepatic uptake of dioscin (diosgenyl 2,4-di-O-a-L-rhamnopyranosyl-p-D-glucopyranoside), an herbal ingredient with antihepatitis activity, in rats and humans. The liver uptake index (LUI) in vivo, perfused rat liver in situ, rat liver slices, isolated rat hepatocytes, and human organic anion-transporting polypeptide (OATP)-trans...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2001
ISSN: 0016-5085
DOI: 10.1053/gast.2001.28704